• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists
【2h】

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

机译：信号传导支架的模块化构建：MORG1与ERK级联的组件相互作用并将ERK信号传导与特定的激动剂链接

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Signal transduction occurs by the reversible assembly of oligomeric protein complexes that include both enzymatic proteins and proteins without known enzymatic activity. These nonenzymatic components can serve as scaffolds or anchors and regulate the efficiency, specificity, and localization of the signaling pathway. Here we report the identification of MORG1 (mitogen-activated protein kinase organizer 1), a member of the WD-40 protein family that was isolated as a binding partner of the extracellular signal-regulated kinase (ERK) pathway scaffold protein MP1. MORG1 specifically associates with several components of the ERK pathway, including MP1, Raf-1, MEK, and ERK, and stabilizes their assembly into an oligomeric complex. MORG1 facilitates ERK activation when cells are stimulated with lysophosphatidic acid, phorbol 12-myristate 13-acetate, or serum, but not in response to epidermal growth factor. Suppression of MORG1 by short interfering RNA leads to a marked reduction in ERK activity when cells are stimulated with serum. We propose that MORG1 is a component of a modular scaffold system that participates in the regulation of agonist-specific ERK signaling.
机译：信号转导通过寡聚蛋白复合物的可逆组装而发生，该复合物包括酶促蛋白和没有已知酶促活性的蛋白。这些非酶组分可以用作支架或锚，并调节信号传导途径的效率，特异性和定位。在这里，我们报告鉴定MORG1（促分裂原激活的蛋白激酶组织者1），它是WD-40蛋白家族的成员，其作为细胞外信号调节激酶（ERK）途径支架蛋白MP1的结合伴侣而被分离。 MORG1专门与ERK途径的几个成分相关联，包括MP1，Raf-1，MEK和ERK，并使它们组装成寡聚复合物稳定。当用溶血磷脂酸，佛波醇12-肉豆蔻酸酯13-乙酸酯或血清刺激细胞时，MORG1促进ERK活化，但不响应表皮生长因子。当用血清刺激细胞时，短干扰RNA抑制MORG1导致ERK活性显着降低。我们建议MORG1是模块化支架系统的一个组件，该系统参与激动剂特异性ERK信号的调节。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号